B12 test for Stella, Keevah and Arthur

I did a DNA test on the little family for B12/Cobalamin malabsorption. Stella’s sister and niece are carriers and even though I am not breeding with Stella, Keevah and Arthur.
I still felt like I wanted to test them to be sure.  All 3 are clear. Yay!

Sadly Wylie is a carrier, but as long as the other ‘parent’ is clear, pups will not be affected.

It is important to test all Aussies as we don’t know how widespread it is.  Especially if you want to breed your Aussie.  It is better to be safe than sorry.  You don’t want to produce a pup that is affected since you could have prevented it.
Cobalamin malabsorption is a hereditary canine health condition that causes the body to be unable to absorb and use vitamin B12 properly, which is required for proper cell development and the functions of the nervous system.

Dogs with HCM (Hereditary Cobalamin Malabsorption) cannot absorb vitamin B12 in the gut.  Cobalamin malabsorbtion can be secondary to (caused by) other diseases but the primary form is hereditary.  Symptoms are highly varied and can mimic many other diseases including exocrine pancreatic insufficiency, porto-systemic (liver) shunt, and early-onset intractable epilepsy.  Severity of the disease is also highly variable; in the worst cases it can be fatal.  Treatment is relatively simple and inexpensive:  Periodic Vitamin B12 shots.

HCM is caused by a single gene and is recessive.  If a dog has HCM both of its parents carry the mutation that causes it.  Dogs affected with HCM should not be bred.  There is a DNA test available so siblings of the affected dog and the grandparents should be tested if they are to be bred.  Those which have the mutation and the parents, which must have it, should be bred only to clear-tested dogs.  If a dog is found to have the mutation, it’s first-step (parents, offspring, and full siblings) which will be used for breeding need to be tested.
Source: http://www.ashgi.org/home-page/genetics-info/metabolic-endocrine/hereditary-cobalamin-malabsorbtion

More info on cobalamin malabsorption: http://www.ashgi.org/home-page/genetics-info/metabolic-endocrine/cobalamin-malabsorbtion-the-devil-you-dont-know

A good place to test your dog in Europe: http://www.animalabs.com/shop/dogs/intestinal-cobalamin-malabsorption-australian-shepherd-type-igs/

And in America: http://research.vet.upenn.edu/Default.aspx?alias=research.vet.upenn.edu/PennGen

Don’t use the test VHL has for IGS. I did use it to check, but it is not a correct test. They haven’t responded to my several emails telling them the test has different outcome then the other two labs above.

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